is arsenic trioxide poisonous

As little as 1-2.5 mg/kg of arsenic trioxide is a potentially fatal dose. Arsenic is a natural component of the earth's crust and is widely distributed throughout the environment in the air, water and land. Gastric lavage was performed, but most of the poison remained as a mass in his stomach. . Toxicity from natural sources of arsenic is rare except from . In addition, some medicines, used to cure certain . Arsenic is an element that is a potent, toxic carcinogen. Forms of arsenic that are more rapidly absorbed are more toxic, while those most rapidly eliminated. The first evidence of the efficacy of arsenic in leukemia was reported in 1882. A total gastrectomy was also performed to avoid intestinal perforation and arsenic poisoning. Organic arsenicals contain arsenic (either trivalent or pentavalent) linked to a carbon atom by a covalent bond. Arsenic Trioxide (1327 -53 -3) LC50 fish 1 > 1 mg/l EC50 Daphnia 1 8.23 mg/l 24 hr. Arsenobetaine and Arsenocholine are the organic forms known as "fish arsenic" and are relatively nontoxic to humans. 0 Metabolism: The metabolism of inorganic arsenic compounds in animals is well known. Signs and symptoms of arsenic poisoning include. What is arsenic? Arsenic is a member of group Va of the periodic table, . . Arsenic trioxide can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. It also can be toxic if on the skin for long amounts of time. As an industrial chemical, whose major uses include in the manufacture of wood preservatives, pesticides, and glass. Arsenic poisoning is a global health issue affecting millions of people worldwide through environmental and occupational exposure, as well as intentional suicide and homicide attempts. Inhalation is the most common exposure in arsenic workers. Arsenic Trioxide is an odorless, colorless to white crystal or powder. Arsenic trioxide was freely available to buy from chemists in rat poisons, tonics or cosmetics. Arsenic was isolated as a distinct compound by Albertus Magnus in 1250. Menu. Arsenic trioxide has shown a strong anti-tumor effect with little toxicity when used in the treatment of acute promyelocytic leukemia (APL). Arsenic trioxide is also being studied in the treatment of other types of cancer. Includes Arsenic Trioxide indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. 4) TRANSFER CRITERIA: Patients with large overdoses or severe . OSHA has set an "action level" of 5 mcg/m . Consult an oncologist, medical toxicologist and/or poison center for assistance in managing patients with overdose. Its mechanisms include regulation of apoptosis and autophagy; promotion of the intracellular production of reactive oxygen species, causing oxidative damage; and inhibition of tumor stem cells. It. It's not understood exactly how it . Is arsenic white? Arsenic is combined with other elements such as oxygen, chlorine, and sulfur to form inorganic arsenic compounds. As little as 1-2.5 mg/kg of arsenic trioxide is a potentially fatal dose. Related pages[ change | change source] Bismuth trioxide Antimony trioxide The main cause of arsenic poisoning is the consumption of a toxic amount of arsenic. Toxicity from natural sources of arsenic is rare except from . Arsenic (As) is a nearly tasteless . Thankfully, progress in science and medicine now allows for the successful use of arsenic in medical treatments. Arsenic trioxide is readily absorbed if ingested or inhaled, but only slowly absorbed through the skin. Fish, bivalve shellfish, and algae also contain arsenic in the form of arsenobetaine and arsenocholine, sometimes referred to as "fish arsenic." Fish arsenic has low toxicity to humans and is rapidly excreted in urine [ATSDR 2007]. MedlinePlus Information on Arsenic Trioxide - A lay language summary of important information about this drug that may include the . A harmless-looking powder, resembling flour or sugar at a quick glance, white arsenic is virtually undetectable in hot food and drink and fatal in small doses. [3] Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia. The brilliant hue of this green pigment, which was used to colour dresses and hair ornaments, was achieved by mixing copper and highly toxic arsenic trioxide or "white arsenic" as it was known. The drug's manufacturer specifically warns that only . All-trans retinoic acid (ATRA) plus arsenic trioxide was found to be noninferior to ATRA plus chemotherapy, and less toxic, in the treatment of acute promyelocytic leukemia. 2007]. Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia. This is an early exampl. Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia.1., 2., 3. Home; Frequently Asked Questions; . According to the American Cancer Society, arsenic trioxide is used to treat leukemia. The relative risk of emerald green bookcloth "depends on. arsenic trioxide synonyms, arsenic trioxide pronunciation, arsenic trioxide translation, English dictionary definition of arsenic trioxide. Ecology - water : Toxic to aquatic life. Arsenic trioxide (an odorless, tasteless, white or transparent, nonflammable solid) is one of the most toxic and prevalent forms of arsenic. Define arsenic trioxide. Arsenious oxide, commonly known as white arsenic, is obtained as a by-product from the roasting of the ores of copper, lead, and certain other metals as well as by the roasting of arsenopyrite and arsenic sulfide ores.. Is arsenic trioxide a poison? What makes arsenic especially dangerous is that it doesn't have a taste or odor, so you can be exposed to it without knowing it. Overview. Even dilute solutions of arsenic trioxide are dangerous on contact with the eyes. The poisonous properties are well known and the subject of an extensive literature. Arsenic is used to manufacture weed killers and insecticides. Exposure to small doses of Arsenic Trioxide over a long time can cause cancer, although small amounts are REQUIRED by the body for proper functioning. Recent studies have shown one form of seaweed, hijiki, to contain high levels of inorganic arsenic [Rose et al. At the same time, it was shown that arsenic trioxide (As 2 O 3 . Arsenic trioxide can cause a serious heart problem. Home; Interviews by Jobs; . Because the vomiting induced by arsenic is likely to remove much of the poison before it can be absorbed into the body, the poisoner often needed to re-dose to kill their victim. Q-T prolongation is a well known and expected effect of arsenic trioxide treatment. No AEGL-2 effects were reported following acute inhalation exposure to arsenic trioxide. Arsenic Trioxide is very toxic, the LD 50 is 14.6 mg/Kg, (Rats). While arsenic is. In the 1990s, researchers from China showed complete clinical remissions in two-thirds of patients with acute promyelocytic leukemia (APL) treated with arsenic, and a survival rate of 60% at 7 years. Control measures This medication is classified as a . Today, an injectable drug made with arsenic trioxide utilizes arsenic's destructive power to target leukemia cancer cells. Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia. In some cases, health care professionals may use the trade name Trisenox when referring to the generic drug name Arsenic Trioxide. [6] If arsenic poisoning occurs over a brief period of time, symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood. Its therapeutic use in leukaemia was described a century ago. Dipyrone: May enhance the adverse/toxic effect of Myelosuppressive Agents. Organic arsenic refers to the kind that is naturally . Arsenic exists in four common valence states. Treatment with arsenic trioxide must be discontinued before the scheduled end of therapy at any time that a hepatotoxicity grade 3 or greater on the National Cancer Institute Common Toxicity Criteria is observed. Section 4 - First Aid Measures Eyes: Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia. 3 Kwong YL, Todd D. Delicious poison: arsenic . After a decline in the use of arsenic during the mid-20th century, arsenic trioxide was reintroduced as an anticancer agent after reports emerged from China of the success of an arsenic trioxide-containing herbal mixture for the treatment of acute promyelocytic leukaemia. n. A poisonous, white amorphous powder, As2O3, used in insecticides, rat poisons, weed killers, pigments, and preservatives for hides and wood. Arsenic could also be given as a series of smaller doses, producing a more subtle form of chronic poisoning characterized by a loss of strength, confusion and paralysis. Arsenic is a deadly poison identified as the cause of acute poisoning in suicide, homicide, and accidents. Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. It affects the digestive system when eaten. The pent valent form is metabolized by reduction into the trivalent form, followed by . The element called arsenic will pass quite safely through the human body provided it remains in that elemental state. It is highly toxic in its inorganic form. Arsenic trioxide is highly toxic when eaten. OTHER NAME(S): Arsenate, Arsenic Pentoxide, Arsenic Trichloride, . Arsenic Trioxide CAS RN: 1327-53-3 Treatment Overview . Inorganic arsenic is generally more toxic than organic arsenic. Arsenic is a deadly poison identified as the cause of acute poisoning in suicide, homicide, and accidents. It was very cheap, a by-product of metal industries, and ordinary Victorians could buy it from their local chemist, or even their grocer, as poison for rats and mice. Arsenic trioxide can cause cancer in humans. Its toxic effects are distinct because it is inhaled, rather than absorbed through the skin or gastrointestinal tract. PDF | Arsenic trioxide (As2O3) has been used medicinally for thousands of years. dehydration. It is very toxic and can enter the biological system through contaminated water, soil and air. Very toxic chemicals, or those that are reproductive hazards or sensitizers, require expert advice on control measures if a less toxic chemical cannot be substituted. 12.2. As III is 60 times more toxic than As V. Organic arsenic is non-toxic whereas inorganic arsenic is toxic. Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia. Other long-term effects include anemia, liver and kidney damage. When arsenic is being referred to as a poison, it is 'white arsenic' or arsenic trioxide, or any of the other poisonous compounds of arsenic being talked about. History and Discovery Arsenic has a been known since prehistoric time and in the Bronze age it was used to make alloys with bronze. Arsenic . ----- 3 Ecological Characteristics: Arsenic trioxide is moderately toxic to birds, slightly toxic to fish and moderately toxic to aquatic invertebrate species. In a detailed independent review of 1000 electrocardiograms from 99 patients on clinical trials, 26 . elemental metallic arsenic - insoluble in water or body fluids and may not be poisonous, but when heated to high temperatures may become the highly toxic form, arsenic trioxide 1; arsenic trisulfide (orpiment) - low toxicity due to minimal solubility, but reported dose-dependent reactions (22541879 J Emerg Med 2013 Feb;44(2):367) Arsenic trioxide is used today as a treatment for some types of leukaemia, and is given intravenously as a low concentration solution due to its toxicity. More About Arsenic Trioxide. Arsenic - more properly arsenic trioxide - is a highly poisonous white powder. It is used to make other Arsenic compounds, in . . We report two cases of acute poisoning with an unwettable formulation of arsenic trioxide. . There are two types of arsenic: organic and inorganic. Arsenic-based chemotherapy drugs, such as arsenic trioxide, are already in use for some cancers. Arsenic has a long history as a poison- a rodent poison in particular - and great lore as a homicidal agent. However, inorganic forms of arsenic have been found in some types of seaweed. arsenic trioxide, leukemia, poisons To the Editor: Lately, arsenic trioxide (As 2 O 3 ) has been described in the treatment of acute myeloid leukemia. To date, only 3 cases of Q-T prolongation above 500 millisecond (ms) have been reported. However, toxic effects resolved with temporary discontinuation of either arsenic trioxide, ATRA or both. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. Arsenic is a deadly poison identified as the cause of acute poisoning in suicide, homicide, and accidents. Historically, arsenic was known as both the "king of poisons" and the "poison of kings," for its toxic power and its popularity among rulers who wanted to quietly do away with their rivals . Arsenic is a naturally occurring element with a reputation as "king of poisons" as well as the "poison of kings." Skip to main content . Arsine (AsH3, a gaseous hydride of arsenic trioxide) is the most toxic of all the arsenicals. Arsenic trioxide, sold under the brand name Trisenox among others, is an inorganic compound and medication. DOI: 10.1007/s12012-018-09504-7 Abstract Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. . Arsenic itself is not poisonous; it is the compounds of arsenic, particularly arsenous oxide or arsenic trioxide (sankhya or somalkhar) and various arsenites of Cu, Na and K that are toxic to the humans. Chemical name : diarsenic trioxide, arsenic trioxide CAS No : 1327-53-3 Product code : LC11505 Formula : As2O3 Synonyms : Arsenous acid / Arseni c (III) oxide / Diarsenic trioxide . This means that it can wreak havoc in the body and promote cancer and disease. Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug. It is available in 10 mL single-use ampules, each of which contains 10 mg arsenic trioxide. Despite its notoriety as a deadly poison, arsenic is an essential trace element for some animals, and maybe even for humans, although the necessary intake may be as low as 0.01 mg/day. Arsenic is a deadly poison identified as the cause of acute poisoning in suicide, homicide, and accidents. It tarnishes rapidly in air, and at high temperatures burns forming a white cloud of arsenic trioxide. Arsenic is a deadly poison identified as the cause of acute poisoning in suicide, homicide, and accidents. loss of appetite mood changes muscle pain or cramps nausea numbness or tingling in hands, feet, or lips seizures sore throat trouble breathing unusual tiredness or weakness vomiting Less common Black, tarry stools bluish lips or skin blurred vision chest pain dizziness or lightheadedness fever flushed, dry skin fruit-like breath odor Arsine (AsH 3), a colourless poisonous gas composed of arsenic and hydrogen, is another familiar arsenic compound. and also a medical preparation called Fowler's solution (used in past for . Menu. Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia. Though a poison, arsenic trioxide is also used in cancer treatments. [1] It was used throughout history as a potent poison to kill off kings and emperors and facilitate rich inheritances. Arsenic is considered to be a heavy metal, and arsenic toxicity shares some similarities with poisonings by other heavy metals. Arsenic trioxide is a component of fruit sprays, weed-killers, dyeing agents, insecticides, rat poisons, etc. nic trioxide | \ rs-nik-, -n-ik- \ Medical Definition of arsenic trioxide : a poisonous trioxide of arsenic As2O3 or As4O6 that is administered intravenously to treat some forms of leukemia and in minute doses is used as a homeopathic remedy Introduction. Workers exposed to arsenic trioxide fumes in their job can be poisoned as well. Persistence and degradability . After the operation, he developed ventricular fibrillation. Arsenic trioxide (As 2 O 3 /As 4 O 6) is a white, odorless powder of low aqueous solubility. 1., 2., 3. An effect on glioma has also been shown. Arsenic pentoxide is formed by the action of an oxidizing agent (e.g., nitric acid) on arsenious oxide. It is ubiquitous in our environment and it is a potent neurological and liver toxin as well as a lung, bladder and skin carcinogen. same application with arsenic trioxide. The gas, also called arsenic hydride, is . Arsenic trioxide is the generic name for the trade name drug Trisenox. Arsenic trioxide poisoning: a description of two acute overdoses Arsenic is a traditional poison that has a history extending back into ancient times, as a medicinal agent, a homicidal poison and more recently in deliberate and unintentional self-poisoning. As a medication, it is used to treat a type of cancer known as acute promyelocytic leukemia. arsenic trioxide is a very effective drug used to treat . Arsine gas is the most toxic arsenical (acute exposure). Drug type: Arsenic Trioxide is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. The organic forms of arsenic found in seafood (mainly arsenobetaine and arsenocholine, also referred to as "fish arsenic") are generally considered to be nontoxic, and are excreted in urine within 48 hours of ingestion [ATSDR 2007]. AEGL-1 values are not proposed, because there were no human or animal data available relating to AEGL-1 endpoints for arsenic trioxide. Show More Overview Uses Side Effects Precautions Interactions Dosing Reviews (5) Overview Arsenic is a trace element. Today, poisons using arsenic are rare; the last person to be convicted of using arsenic as a poison was Marcus Marymont, a US sergaent, who in 1958 used white arsenic to poison his wife. Humans have exploited its toxic properties in weed killers, fungicides and insecticides, especially in vineyards, apple orchards, and cotton and tobacco fields. The water solubility of arsenic salts varies depending on the salt. Arsenic Trioxide (As 2 O 3, CAS#: 1327-53-3): toxic glassy, amorphous lumps or crystal compound; slightly soluble in water; octahedral crystals change to the monoclinic form by heating at 200C; arsenious acid; occurs naturally as arsenolite and claudetite; used in some medicinal preparations but in . It was cheap and was a perfectly normal addition to any shopping list. Arsenic is extremely poisonous to humans. What most people mean by arsenic is the compound arsenic trioxide, known in the 1800s as white arsenic. Forms of arsenic that are more rapidly absorbed are more toxic, while those most rapidly eliminated. Exposure to higher-than-average levels of arsenic occurs mainly in workplaces, near or in hazardous waste sites, and areas with high levels . Arsenic is a deadly poison identified as the cause of acute poisoning in suicide, homicide, and accidents. Arsenic Trioxide, As 2 O 3, is the most frequently found Arsenic compound. This drug is formulated as a sterile, injectable solution of arsenic trioxide. People are exposed to elevated levels of inorganic arsenic through drinking contaminated water, using contaminated water in food preparation and irrigation of food crops . Inorganic arsenic is generally more toxic than organic arsenic. [17] [18] [19] Chronic arsenic poisoning is known as arsenicosis. "Arsenic is a heavy metal and does have some toxicity associated with it, principally, either inhalation or ingestion," he says. It comprises a major ingredient of insecticides, herbicides, and metal adhesives. Top of Page Key Points Arsenic is an element and is a naturally occurring mineral found widely in the environment. nausea, vomiting, abdominal pain, diarrhea, dark urine, and. Is arsenic trioxide safe? No deaths due to cardiac arrhythmias have been attributed to Trisenox. Specifically, the risk for agranulocytosis and pancytopenia . When exposed to this toxin, we can get all sorts of symptoms and health problems. Physicians would apply powered arsenic to wounds and skin lesions, often with fatal outcomes. Chronic exposure to arsenical dust may cause shortness of breath, nausea, chest pains, and garlic odor. Arsenicum Album Arsenic toxicity inactivates up to 200 enzymes, most notably those involved in cellular energy pathways and DNA replication and repair, and is substituted for phosphate in high energy compounds such as ATP. Abstract In a suicide attempt, a 54-year-old man ingested arsenic trioxide. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. Although arsenic homicides commonly receive media publicity, the primary source of arsenic toxicity to the general population is by contaminated water, soil and food products. Eventually, the arsenic of choice emerged as so-called white arsenic or arsenic trioxide (As2O3); the fatal dose was known to be an amount equivalent in size to a pea. Arsenic as a pure element would not be as poisonous as it cannot be absorbed by the human body in significant amounts. Trivalent arsenic, better known as arsenic trioxide, is the active ingredient in Trisenox at a concentration of 1.0 mg/mL. Arsenic occurs naturally in the environment as an element of the earth's crust.

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